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Trained Immunity

β-Glucan can reprogram innate immunity into a “trained” state that sometimes enhances vaccines and cancer therapies, but can also worsen inflammation in lungs and bone, thus making it a powerful, double-edged tool rather than a simple immune booster. 

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    Written by:
    1. Beta Glucan PhD Team,

      Beta Glucan PhD Team

      Beta Glucan PhD Team

    We analyze peer-reviewed research on supplements.

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    1. Kalafati Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity 2020
    2. Dos Santos β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: A Crucial Role for IL-32 2019
    3. Khan β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus 2025
    4. Ding Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis 2024
    5. Geller The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression 2022
    6. Haacke Innate immune training of osteoclastogenesis promotes inflammatory bone loss in mice 2025
    7. Prevel β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury 2025
    8. Vuscan Microbial-induced trained immunity for cancer immunotherapy 2025
    9. Cheung Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma 2022
    10. Rodriguez Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) 2021

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