Icon


  1. Beta Glucan
  2. Inflammation

Inflammation

Beta-glucan is a natural compound found in oats, mushrooms, and yeast. It has been studied for its potential to reduce inflammation by balancing immune responses, protecting tissues, and improving gut health. Early research shows promise for conditions such as gut disease, autoimmune disorders, infections, and certain cancers, but most evidence comes from preclinical animal or laboratory studies, and further human trials are needed to confirm safety, effectiveness, and dosing.

We analyze peer-reviewed research on supplements.

We rely on peer-reviewed scientific research to determine what’s truly effective. Our goal is to provide clear, unbiased information to help you make better health decisions.

We use AI tools to help summarize studies, and every piece of content is reviewed and approved by qualified experts, ensuring it’s accurate and trustworthy.

Beta Glucan is fully independent — we don’t sell products, run ads, or accept sponsorships. Our only focus is delivering reliable, science-backed insights.

Podcast

Beta Glucans: The Master Key to Anti-Inflammatory

00:00
-00:00

Download PDF Protocol

Download Protocol

A special yeast cell-wall sugar (MGCP) calmed inflammation and protected mice from colitis and a multiple-sclerosis–like diseaseNew

A yeast fiber (β-glucan) trained gut immunity and gut bacteria and helped delay type 1 diabetes (T1D) progression in miceNew

Yeast-derived β-glucan improved saliva flow and immune markers in a Sjögren’s-like mouse model and tracked with T-cell changes seen in patientsNew

Daily fiber drinks did not stop a painkiller-related “leaky gut” effect in older adults after 6 weeks. New

“Refined” lab diets sped up aging-like problems in mouse liver and brain; adding fiber slowed memory decline but didn’t fix liver issues. New

Yeast fiber reshaped the gut, calmed brain inflammation, and eased Alzheimer-like changes in high-fat-fed rats. New

Two weeks of yeast β-glucan eased post-exercise inflammation in the heat and helped keep mood up, but didn’t reduce muscle damageNew

Yeast β-glucan may help the body’s first-line defenses respond more effectively after exerciseNew

A month of daily β-glucan modestly boosted grip strength and fitness in young athletes and shifted blood molecules linked to the body’s creatine energy systemNew

Breathe Easy? Pleuran (Mushroom Extract from β-(1,3/1,6)-D-glucan) May Help Kids with AsthmaNew

  1. Zabriskie Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise 2020
  2. McFarlin Baker's yeast beta glucan supplementation was associated with an improved innate immune mRNA expression response after exercise 2024
  3. Mo Yeast β-glucan alleviates high-fat diet-induced Alzheimer's disease-like pathologies in rats via the gut-brain axis 2024
  4. Huang Oat β-glucan enhances gut barrier function and maintains intestinal homeostasis in naturally aging mice 2025
  5. Kromm Aging-related decline in the liver and brain is accelerated by refined diet consumption 2025
  6. Mall Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial 2020
  7. Pan Alterations in CD8+CD45RA+CCR7- T cells as a potential biomarker for primary Sjögren's syndrome 2025
  8. Gudi Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes 2019
  9. Lee Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities 2021
  10. Sato Curdlan, a Microbial β-Glucan, Has Contrasting Effects on Autoimmune and Viral Models of Multiple Sclerosis 2022
  11. Choi Autoantibody-Mediated Dysfunction of Salivary Glands Leads to Xerostomia in SKG Mice 2019
  12. Fahlquist-Hagert Variants of beta-glucan polysaccharides downregulate autoimmune inflammation 2022
  13. Zheng Polyporus Umbellatus polysaccharide ameliorates rheumatoid arthritis via inhibiting inflammation and regulating gut microbiota 2025
  14. Sreih Role of macrophage migration inhibitory factor in granulomatosis with polyangiitis 2019
  15. He Deciphering immunoregulatory mechanisms and structure-guided biosynthesis of β-glucans 2025
  16. Kalia The role of dectin-1 in health and disease 2021
  17. Kulkarni Association Between the Gut Microbiota and Alzheimer's Disease: An Update on Signaling Pathways and Translational Therapeutics 2025
  18. Wu Qingke β-glucan and Lactobacillus mitigate neuroinflammation and enhance cognitive function in an Alzheimer's disease mouse model 2025
  19. Zhang β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites 2023
  20. Xu Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1-42-induced AD-like mice 2020

Stay up to date with the latest research

Become an Beta Glucan Insider to stay on top of the latest nutrition research, supplement myths, and more