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Alzheimer's

Early evidence suggests yeast and barley β-glucans may modestly influence Alzheimer’s via the gut (reshaping microbes, increasing short-chain fatty acids, strengthening the intestinal barrier, and dialing down neuroinflammation) with cognition gains shown in mice; a placebo-controlled human trial is underway, so efficacy and safety remain unproven.

    Written by:
    1. Beta Glucan PhD Team,

      Beta Glucan PhD Team

      Beta Glucan PhD Team

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    Podcast

    Beta Glucans and Alzheimer's

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    A daily yeast fiber (β-glucan) improved memory and brain health in an Alzheimer’s-like mouse model by fixing gut bacteria and key brain signalsNew

    A month of treatment on yeast-fiber (β-glucan) improved memory and reduced brain inflammation in an Alzheimer’s-like mouse model, partly by changing gut bacteria and their secreted chemicalsNew

    Long-term yeast β-glucan reshapes the gut to protect the brain from Alzheimer's like symptoms caused by high-fat-diet in ratsNew

    Barley β-glucan plus gut-friendly bacteria eased brain changes and improved memory in an Alzheimer’s-like mouse modelNew

    Can a fiber-like supplement from yeast help the gut talk to the brain in Alzheimer’s disease?New

    1. Wu Qingke β-glucan and Lactobacillus mitigate neuroinflammation and enhance cognitive function in an Alzheimer's disease mouse model 2025
    2. Mo Yeast β-glucan alleviates high-fat diet-induced Alzheimer's disease-like pathologies in rats via the gut-brain axis 2024
    3. Zhang β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites 2023
    4. Xu Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1-42-induced AD-like mice 2020
    5. Kulkarni Association Between the Gut Microbiota and Alzheimer's Disease: An Update on Signaling Pathways and Translational Therapeutics 2025
    6. Raghavan Benefits of Gut Microbiota Reconstitution by Beta 1,3–1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases 2022

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