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Clinical Trials

Clinical trials suggest beta-glucan can have modest benefits on infection, immunity or metabolism, but outcomes depend strongly on the beta-glucan’s source, structure, dose, and how it’s delivered.

    Written by:
    1. Beta Glucan PhD Team,

      Beta Glucan PhD Team

      Beta Glucan PhD Team

    We analyze peer-reviewed research on supplements.

    We rely on peer-reviewed scientific research to determine what’s truly effective. Our goal is to provide clear, unbiased information to help you make better health decisions.

    We use AI tools to help summarize studies, and every piece of content is reviewed and approved by qualified experts, ensuring it’s accurate and trustworthy.

    Beta Glucan is fully independent — we don’t sell products, run ads, or accept sponsorships. Our only focus is delivering reliable, science-backed insights.

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    Chewable mushroom β-glucan (with vitamin D and zinc) cut kids’ colds and other respiratory infections by about 15% over three months.New

    Can a “memory boost” for white blood cells help cancer treatments work better?New

    Yeast Beta-Glucan Improves Metabolic and Inflammatory Markers in Obese Dogs with Insulin ResistanceNew

    A beta-glucan plus selenium and zinc supplement improved micronutrient status and showed non-significant immune-response trends after influenza or COVID-19 vaccination.New

    Yeast Beta-glucan (β-glucan) Supplements Show Promise in Reducing Severe Inflammation and Clotting Risks in COVID-19 PatientsNew

    An Alpha-glucan (⍺-glucan) Supplement Shows Promise for Easing Chronic Symptoms and Inflammation in Lyme Disease PatientsNew

    A Yeast Beta Glucan (β-glucan) Capsule Supplement Reduces the Severity of Cold Symptoms in Immunocompromised AdultsNew

    A Daily Beta Glucan (β-glucan) Supplement May Boost Flu Shot Benefits in Older AdultsNew

    Beta Glucan (β-glucan) Enhances Antibody Response Following Flu Vaccination in Older AdultsNew

    A β-glucan Drink Supplement Reduces the Severity of Cold Symptoms in Marathon Runners New

    1. Murphy β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application 2020
    2. Jesenak Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial 2025
    3. Moreno Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination - A Double-Blind, Randomized, Placebo-Controlled Pilot Trial. 2025
    4. Wzorek-Łyczko A randomised trial of pleuran in paediatric acute gastroenteritis 2025
    5. Reiners Effect of a regular consumption of traditional and roasted oat and barley flakes on blood lipids and glucose metabolism–A randomized crossover trial 2023
    6. Hjorth Effectiveness of regular oat β-glucan–enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial 2025
    7. Rioux-Labrecque Supplementation with a β-glucan tablet has no effect on hyperlipidemia: a randomized, placebo-controlled clinical trial 2023
    8. Garcia-Cordero Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention 2023
    9. Morales Modulation of human intestinal microbiota in a clinical trial by consumption of a β‑d‑glucan‑enriched extract obtained from Lentinula edodes 2021
    10. Wolever Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains 2021
    11. Mah Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial 2020
    12. Dharsono Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects 2019
    13. Salerno A Pilot Open-Label Study Assessing the Effects of AHCC Supplementation on Lyme Disease Patients 2019
    14. Raghavan Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study 2021
    15. Rodriguez Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) 2021
    16. Ferriera Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan 2022
    17. Nakayama Immunogenicity, safety, and tolerability of a β-glucan-CpG-adjuvanted respiratory syncytial virus vaccine in Japanese healthy participants aged 60 to 80 years: A phase 2, randomized, double-blind, dose-finding study 2025
    18. Vuscan Microbial-induced trained immunity for cancer immunotherapy 2025
    19. Moreno Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination – A Double-Blind, Randomized, Placebo-Controlled Pilot Trial 2025
    20. Wolever An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial 2021

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