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Chronic Fatigue

Beta-glucans from oats, yeast, and Euglena may modestly ease fatigue and support recovery by tempering inflammation, bolstering antioxidant defenses, and conserving energy stores with early human and animal studies suggesting source-dependent benefits with generally good short-term safety.

    Written by:
    1. Beta Glucan PhD Team,

      Beta Glucan PhD Team

      Beta Glucan PhD Team

    We analyze peer-reviewed research on supplements.

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    In a 4-week study, oat β-glucan drinks slightly eased headaches (and a few other complaints) in adults; these results are promising but preliminary.New

    Across clinical trials in healthy people, β-glucan supplements were linked to less fatigue and better energy/mood.New

    A month of a microalgae β-glucan (paramylon) modestly eased fatigue feelings and steadied attention during long computer tasks.New

    A daily Euglena (β-glucan) supplement for 3 months was linked to fewer and milder colds and less tiredness in endurance-trained adultsNew

    Four weeks of oat beta-glucan intake was associated with modest improvements in self-reported fatigue and selected feeling-state symptoms in adults with borderline-high LDL cholesterol.New

    Short-term yeast beta-glucan supplementation reduced selected inflammatory signals after heat-stressed exercise without altering muscle damage or strength outcomes.New

    Purified oat beta-glucan increased treadmill endurance and shifted fatigue-related metabolic markers in trained rats.New

    In male mice, 28 days of the water-soluble beta-glucan Salecan was associated with longer swim-to-exhaustion time and more favorable post-exercise biomarkers compared with untreated swim controls.New

    Yeast Beta-Glucan With Multivitamins Shows Modest Cognitive Fatigue Benefit in ME/CFSNew

    1. Wolever Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains 2021
    2. Lacasa Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial 2023
    3. Zabriskie Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise 2020
    4. Evans Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial 2019
    5. Muroya Effects of β-glucans on fatigue: a systematic review and meta-analysis 2025
    6. Kawano Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial 2020
    7. Xu β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice 2018
    8. Xu Effects of oat β-glucan on endurance exercise and its anti-fatigue properties in trained rats 2013
    9. Wolever An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial 2021

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