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Stress and Mood

Beta-glucans may offer modest support for stress and mood by influencing immune and inflammatory pathways linked to how people feel. Across studies, certain forms show small improvements in fatigue, energy, and overall wellbeing. Effects vary by source, dose, and population, so beta-glucans should be viewed as supportive, not therapeutic.

    Written by:
    1. Beta Glucan PhD Team,

      Beta Glucan PhD Team

      Beta Glucan PhD Team

    We analyze peer-reviewed research on supplements.

    We rely on peer-reviewed scientific research to determine what’s truly effective. Our goal is to provide clear, unbiased information to help you make better health decisions.

    We use AI tools to help summarize studies, and every piece of content is reviewed and approved by qualified experts, ensuring it’s accurate and trustworthy.

    Beta Glucan is fully independent — we don’t sell products, run ads, or accept sponsorships. Our only focus is delivering reliable, science-backed insights.

    Podcast

    Stress & Your Immune System

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    Yeast β-Glucan Particles Activate Immune Metabolism and Support Trained ImmunityNew

    Undenatured Beta-Glucans in Stressed Marine Life: Survival and Immune Response SignalsNew

    Evidence From Human Trials on Fungal Beta-Glucans and Health OutcomesNew

    In a 4-week study, oat β-glucan drinks slightly eased headaches (and a few other complaints) in adults; these results are promising but preliminary.New

    Across clinical trials in healthy people, β-glucan supplements were linked to less fatigue and better energy/mood.New

    Four weeks of oat beta-glucan intake was associated with modest improvements in self-reported fatigue and selected feeling-state symptoms in adults with borderline-high LDL cholesterol.New

    Short-term yeast beta-glucan supplementation reduced selected inflammatory signals after heat-stressed exercise without altering muscle damage or strength outcomes.New

    Yeast-Based β-glucan May Provide Mood Boosting and Allergy Relief New

    1. Vlassopoulou Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials 2021
    2. Muroya Effects of β-glucans on fatigue: a systematic review and meta-analysis 2025
    3. Wolever Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains 2021
    4. Johnston Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity 2024
    5. Kristiansen The Positive Effects of Proprietary Undenatured β-Glucans on Stressed Marine Life 2022
    6. Talbott β-Glucan supplementation, allergy symptoms, and quality of life in self-described ragweed allergy sufferers 2013
    7. Zabriskie Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise 2020
    8. Wolever An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial 2021

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