The role of glucan in stimulation of immune reactions has been well-established. In this report, we focused
on the antibody production in glucan-supplemented children with chronic respiratory problems. We
measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effects
of 100 mg d−1
oral dose of glucan. We found a significant increase in production of all tested antibodies in
the glucan-stimulated group, but a decrease of antibody production in the control group. A thirty-day oral
application of yeast-based natural immunomodulator β-glucan strongly stimulated the mucosal immunity of
children with chronic respiratory problems.