A comparison of injected and orally administered β-glucans

Abstract

β-glucans have been extensively studied for their pharmacological effects. Despite in-depth research, little is known about the optimal dose and/or optimal route of application. In this paper, we are reporting the result of comparing the immunostimulating activities of four commercially available glucans differing both in their solubility and source. In addition, we compared intraperitoneal and oral application, and the differences between a single versus repeated doses. Our data showed strong differences in activities of individual glucans, with glucan yeast-derived #300 being the best, and grain-derived ImmuneFiber being the worst. Furthermore, we demonstrated that oral delivery of glucan resulted in significant immunological activity, which albeit slightly lower, corresponded with injectable application. Depending on the applied dose, the effects of individual glucans were long-lasting and in some cases, lasted up to two weeks. In conclusion, our report represents further evidence about differences among commercial glucans and shows that these biological response modifiers can be similarly active when used in both injectable and oral form.

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