β-glucans have been extensively studied for their pharmacological effects. Despite in-depth research, little is
known about the optimal dose and/or optimal route of application. In this paper, we are reporting the result of comparing the immunostimulating activities of four commercially
available glucans differing both in their solubility and
source. In addition, we compared intraperitoneal and oral
application, and the differences between a single versus
Our data showed strong differences in activities of individual glucans, with glucan yeast-derived #300 being the
best, and grain-derived ImmuneFiber being the worst.
Furthermore, we demonstrated that oral delivery of glucan
resulted in significant immunological activity, which albeit
slightly lower, corresponded with injectable application.
Depending on the applied dose, the effects of individual
glucans were long-lasting and in some cases, lasted up to
In conclusion, our report represents further evidence
about differences among commercial glucans and shows
that these biological response modifiers can be similarly
active when used in both injectable and oral form.